The Science Behind Bioavailable CBD 

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The science of Pro Nano Lipospheres (PNLs) found in nanoemulsions explains why our CBD absorption is close to 100% via topical application

Research has shown that Pro Nano Lipospheres (PNLs) found in nanoemulsions enable the safe delivery of poorly water soluble compounds such as CBD and are used medically as a drug delivery system.  (Zgair et al., 2016)

Cannabinoids such as CBD are naturally produced in our bodies – and are naturally present in breast milk. These compounds are received by a complex network of cannabinoid receptors throughout the human brain and body. The compounds promote a steady internal physical and chemical balance, known as homeostasis, within the body all the way down to the sub-cellular level. You can supplement your body’s own cannabinoid production with CBD.

CBD has shown therapeutic efficacy in various medical conditions (Bruni et al 2018). CBD molecules are poorly water-soluble and subjected to extensive first- pass metabolism in the gastrointestinal tract, leading to a limited oral bioavailability of approximately 9% (Cherniakov et al 2017)

Research has shown that Pro Nano Lipospheres (PNLs) found in nanoemulsions enable the safe delivery of poorly water-soluble compounds such as CBD and are used medically as a drug delivery system. (Zgair et al., 2016)

As you can see in Fig.1 there is a very significant improvement in CBD blood absorption with the CBD NANO compared to CBD

CBD Nanoemulsions

Fig.1 Plasma CBD concentration vs. time plot (mean ± SEM) following PO administration of CBD, CBD-PNL and CBDCurcumin- PNL. CBD dose 15 mg/kg. Curcumin dose of 10 mg/kg (n =6 for each group) (Cherniakov et al 2017)

Nanoemulsions

Nanoemulsions are very common in the food & beverage industry and include such familiar products as milk, espresso cream, vinaigrette, mayonnaise, etc.  Nanoparticles called “mixed micelles” are naturally formed in the small intestine during the lipid digestion process. It is the body’s own “nanotechnology”, which it uses to make oily substances water-compatible in order to transport and absorb them. When correctly formulated, nanoemulsions simply mimic these mixed micelles and, therefore, improve the absorption process.

Nanoemulsions: Use Cases

Our CBD nanoemulsion is a perfect addition to any cosmetics and stands alone as a great topical application as it is. Our product mixes well with most formulations, or in difficult cases, can be combined with mixing agents which will allow for successful mixing.

Due to our technology, CBD absorption is close to 100% via topical application and does not leave an oily residue on the skin but acts as a moisturizer.

CBD has been shown to work well for patients suffering from inflammatory conditions including arthritis as well as skin conditions such as psoriasis (Burstein 2015, Noroozneshad and Noroozneshad 2016

Cited Peer-Review Literature. 

S. Burstein Bioorganic & Medicinal Chemistry 23 (2015) 1377–1385

Bruni  N, Della Pepa  C, Oliaro-Bosso  S, Pessione  E, Gastaldi  D, Dosio  F.  Cannabinoid delivery systems for pain and inflammation treatment.  Molecules. 2018;23(10): E2478

Cherniakov, I.; Izgelov, D.; Domb, A.J.; Hoffman, A. The effect of Pro NanoLipospheres (PNL) formulation containing natural absorption enhancers on the oral bioavailability of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in a rat model. Eur. J. Pharm. Sci. 2017, 109, 21–30.

A.N Noroozneshad and F. Noroozneshad Medical Hypotheses 99 (2017) 15–18

Zgair, A., Wong, J.C.M., Lee, J.B., Mistry, J., Sivak, O., Wasan, K.M., Hennig, I.M., Barrett, D.A., Constantinescu, C.S., Fischer, P.M., Gershkovich, P., 2016. Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines. Am. J. Transl. Res. 8 (8), 3448–3459.

Cannabinoids are naturally produced in your body and are a natural component of breast milk. Cannabinoids promote homeostasis at the cellular level. You can supplement your body’s own cannabinoid production with CBD.

There is a significant improvement in CBD blood absorption with CBD Nano compared to CBD alone.

Due to our nanoemulsion technology, CBD absorption is close to 100% via topical application and leaves no oily residue.

Your customers are waiting.

Unique Therapeutics is your preferred supplier for pure, water-soluble CBD Nano for use in your cosmetics, skincare, health and wellness products and pet formulations.

We supply bulk CBD nanoemulsion.

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